Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC005
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2023-02-06 12:19
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment CARBOMA 150MG 4X1 MADOPAR HBS 2X1 OPRIMEA 0,52 1X1

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 15 individuals with a value less than 0.56 were subsequently diagnosed with PD. That is, 35.71% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.56 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 42, 'TN': 30, 'TP': 0, 'FP': 0}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 26, 'TN': 22, 'TP': 16, 'FP': 8}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 0, 'TN': 0, 'TP': 42, 'FP': 30}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 3.452
timePerCircleCoV 0.249605
timePerCircleSlope -0.0400997
meanError 3.30777
tremorFreq 8.88672
tremorRelPower 24.6131
tremorGyroAmpMean 0.0552743
tremorGyroAmpSlope -0.0206693
tremorGyroAmpCoV 0.37783
tremorCoordAmpMean 0.246912
tremorCoordAmpSlope 0.0492578
tremorCoordAmpCoV 1.21541
tremorAccAmpMean 0.126905
tremorAccAmpSlope -0.0387099
tremorAccAmpCoV 0.289946
tremorPcRelVar 0.772111
tremorPcX -0.350639
tremorPcY 0.936511

Circle Segment 1

Duration 5.4 s, Accuracy Estimate 4.372 (lower is better)

Circle Segment 2

Duration 3.96 s, Accuracy Estimate 1.965 (lower is better)

Circle Segment 3

Duration 3.28 s, Accuracy Estimate 2.564 (lower is better)

Circle Segment 4

Duration 3.08 s, Accuracy Estimate 2.374 (lower is better)

Circle Segment 5

Duration 3.04 s, Accuracy Estimate 3.195 (lower is better)

Circle Segment 6

Duration 3.44 s, Accuracy Estimate 1.973 (lower is better)

Circle Segment 7

Duration 2.72 s, Accuracy Estimate 2.427 (lower is better)

Circle Segment 8

Duration 2.52 s, Accuracy Estimate 2.642 (lower is better)

Circle Segment 9

Duration 2.88 s, Accuracy Estimate 6.923 (lower is better)

Circle Segment 10

Duration 4.2 s, Accuracy Estimate 4.643 (lower is better)

Spiral

numSpirals 11
timePerSpiralMean 7.74545
timePerSpiralCoV 0.136093
timePerSpiralSlope -0.00953052
meanError 3.39783
tremorFreq 8.30078
tremorRelPower 29.9866
tremorGyroAmpMean 0.0737978
tremorGyroAmpSlope -0.00213174
tremorGyroAmpCoV 0.271251
tremorCoordAmpMean 0.566764
tremorCoordAmpSlope -0.0091427
tremorCoordAmpCoV 0.883807
tremorAccAmpMean 0.127995
tremorAccAmpSlope -0.00614544
tremorAccAmpCoV 0.251127
tremorPcRelVar 0.545668
tremorPcX -0.799688
tremorPcY 0.600416

Spiral Segment 1

Duration 9.36 s, Accuracy Estimate 2.556 (lower is better)

Spiral Segment 2

Duration 7.08 s, Accuracy Estimate 3.229 (lower is better)

Spiral Segment 3

Duration 7.0 s, Accuracy Estimate 5.549 (lower is better)

Spiral Segment 4

Duration 7.44 s, Accuracy Estimate 4.111 (lower is better)

Spiral Segment 5

Duration 6.68 s, Accuracy Estimate 3.643 (lower is better)

Spiral Segment 6

Duration 9.56 s, Accuracy Estimate 2.78 (lower is better)

Spiral Segment 7

Duration 8.72 s, Accuracy Estimate 4.009 (lower is better)

Spiral Segment 8

Duration 8.24 s, Accuracy Estimate 2.436 (lower is better)

Spiral Segment 9

Duration 7.32 s, Accuracy Estimate 2.84 (lower is better)

Spiral Segment 10

Duration 6.6 s, Accuracy Estimate 3.298 (lower is better)

Spiral Segment 11

Duration 7.2 s, Accuracy Estimate 2.926 (lower is better)

Elel

eDurationMean 0.28087
eDurationStd 0.0542019
eDurationStdnorm 0.192979
eDurationMedian 0.275
eDurationQuartdelta 0.06125
eDurationQuartdeltanorm 0.222727
eDurationKurt 4.01772
eDurationTrenddiff -0.01
eDurationTrendratio 0.963636
eWidthMean 4.73087
eWidthStd 2.03594
eWidthStdnorm 0.430353
eWidthMedian 4.329
eWidthQuartdelta 2.42775
eWidthQuartdeltanorm 0.560811
eWidthKurt 3.85597
eWidthTrenddiff -0.117
eWidthTrendratio 0.973684
eHeightMean 8.44435
eHeightStd 1.9917
eHeightStdnorm 0.235862
eHeightMedian 8.307
eHeightQuartdelta 1.989
eHeightQuartdeltanorm 0.239437
eHeightKurt 3.239
eHeightTrenddiff -1.521
eHeightTrendratio 0.835443
eAspectMean 0.568659
eAspectStd 0.226056
eAspectStdnorm 0.397525
eAspectMedian 0.504673
eAspectQuartdelta 0.255022
eAspectQuartdeltanorm 0.505322
eAspectKurt 4.09204
eAspectTrenddiff 0.0734127
eAspectTrendratio 1.15226
eSlantMean -0.578133
eSlantStd 0.404602
eSlantStdnorm -0.699843
eSlantMedian -0.746032
eSlantQuartdelta 0.495688
eSlantQuartdeltanorm -0.664433
eSlantKurt 3.97522
eSlantTrenddiff -0.108532
eRtopMean 0.476548
eRtopStd 0.264319
eRtopStdnorm 0.554654
eRtopMedian 0.481481
eRtopQuartdelta 0.331864
eRtopQuartdeltanorm 0.689255
eRtopKurt 2.60347
eRtopTrenddiff -0.022022
eRbotMean 1.72112
eRbotStd 0.798859
eRbotStdnorm 0.464149
eRbotMedian 1.63636
eRbotQuartdelta 1.4207
eRbotQuartdeltanorm 0.868206
eRbotKurt 2.19107
eRbotTrenddiff 0.0494071
eRrightMean 0.668346
eRrightStd 0.208496
eRrightStdnorm 0.311959
eRrightMedian 0.6875
eRrightQuartdelta 0.275571
eRrightQuartdeltanorm 0.400831
eRrightKurt 2.47423
eRrightTrenddiff 0.0907268
eRleftMean 0.636355
eRleftStd 0.196946
eRleftStdnorm 0.309491
eRleftMedian 0.650794
eRleftQuartdelta 0.284936
eRleftQuartdeltanorm 0.437828
eRleftKurt 3.92264
eRleftTrenddiff 0.15557
lDurationMean 0.39119
lDurationStd 0.0744296
lDurationStdnorm 0.190264
lDurationMedian 0.38
lDurationQuartdelta 0.105
lDurationQuartdeltanorm 0.276316
lDurationKurt 2.98048
lDurationTrenddiff -0.06
lDurationTrendratio 0.850932
lWidthMean 4.61314
lWidthStd 2.18623
lWidthStdnorm 0.473914
lWidthMedian 4.797
lWidthQuartdelta 4.0365
lWidthQuartdeltanorm 0.841463
lWidthKurt 1.68979
lWidthTrenddiff 1.053
lWidthTrendratio 1.26087
lHeightMean 21.4723
lHeightStd 4.5333
lHeightStdnorm 0.211123
lHeightMedian 20.592
lHeightQuartdelta 6.58125
lHeightQuartdeltanorm 0.319602
lHeightKurt 2.15719
lHeightTrenddiff -6.552
lHeightTrendratio 0.738318
lAspectMean 0.221664
lAspectStd 0.109806
lAspectStdnorm 0.49537
lAspectMedian 0.234568
lAspectQuartdelta 0.173085
lAspectQuartdeltanorm 0.737888
lAspectKurt 2.16732
lAspectTrenddiff 0.134289
lAspectTrendratio 1.87188
lSlantMean -0.468334
lSlantStd 0.270562
lSlantStdnorm -0.577711
lSlantMedian -0.522727
lSlantQuartdelta 0.357825
lSlantQuartdeltanorm -0.684535
lSlantKurt 2.35615
lSlantTrenddiff -0.270517
lRtopMean 0.410315
lRtopStd 0.253637
lRtopStdnorm 0.618151
lRtopMedian 0.317073
lRtopQuartdelta 0.340177
lRtopQuartdeltanorm 1.07287
lRtopKurt 2.84798
lRtopTrenddiff 0.105372
lRbotMean 3.05997
lRbotStd 1.86161
lRbotStdnorm 0.608375
lRbotMedian 2.5625
lRbotQuartdelta 1.55569
lRbotQuartdeltanorm 0.607098
lRbotKurt 4.62083
lRbotTrenddiff 0.12523
lRrightMean 0.664675
lRrightStd 0.171964
lRrightStdnorm 0.258719
lRrightMedian 0.650685
lRrightQuartdelta 0.285752
lRrightQuartdeltanorm 0.439156
lRrightKurt 1.95551
lRrightTrenddiff -0.00215778
lRleftMean 0.712362
lRleftStd 0.219352
lRleftStdnorm 0.307922
lRleftMedian 0.778409
lRleftQuartdelta 0.391764
lRleftQuartdeltanorm 0.503288
lRleftKurt 1.75131
lRleftTrenddiff 0.287237

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.846214
sumTouchScores 29.6175
meanMovementTime 0.575
numTouches 35
undershootPercentage 0
overshootPercentage 25.7143

FITTS Long Modified

meanTouchScore 0.746915
sumTouchScores 18.6729
meanMovementTime 0.77875
numTouches 25
undershootPercentage 4
overshootPercentage 32

ZigZag

numZigzags 5
timePerZigzagMean 8.328
timePerZigzagCoV 0.0400992
timePerZigzagSlope -0.0100865
meanError 3.50506
tremorFreq 6.15234
tremorRelPower 25.0181
tremorGyroAmpMean 0.121733
tremorGyroAmpSlope -0.00802748
tremorGyroAmpCoV 0.297352
tremorCoordAmpMean 0.221159
tremorCoordAmpSlope -0.00961738
tremorCoordAmpCoV 0.243722
tremorAccAmpMean 0.18928
tremorAccAmpSlope -0.00922722
tremorAccAmpCoV 0.228148
tremorPcRelVar 0.574545
tremorPcX -0.954336
tremorPcY 0.298735

ZigZag Segment 1

Duration 8.72 s, Accuracy Estimate 3.419 (lower is better)

ZigZag Segment 2

Duration 8.44 s, Accuracy Estimate 3.609 (lower is better)

ZigZag Segment 3

Duration 7.96 s, Accuracy Estimate 2.977 (lower is better)

ZigZag Segment 4

Duration 8.0 s, Accuracy Estimate 3.599 (lower is better)

ZigZag Segment 5

Duration 8.52 s, Accuracy Estimate 3.92 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 6.872
timePerZigzagCoV 0.076049
timePerZigzagSlope -0.0337602
zigzagHeightMean 64.8168
zigzagHeightCoV 0.113268
zigzagHeightSlope 0.0618227
meanError 0.0506329
tremorFreq 7.8125
tremorRelPower 28.8645
tremorGyroAmpMean 0.0944829
tremorGyroAmpSlope 8.54167e-05
tremorGyroAmpCoV 0.250945
tremorCoordAmpMean 0.247469
tremorCoordAmpSlope -0.0115411
tremorCoordAmpCoV 0.27593
tremorAccAmpMean 0.186995
tremorAccAmpSlope -0.0155983
tremorAccAmpCoV 0.316261
tremorPcRelVar 0.771246
tremorPcX -0.554917
tremorPcY -0.831906

ZigZag Offset Segment 1

Duration 7.12 s, Accuracy Estimate 0.044 (lower is better)

ZigZag Offset Segment 2

Duration 7.0 s, Accuracy Estimate 0.04 (lower is better)

ZigZag Offset Segment 3

Duration 7.28 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 4

Duration 7.0 s, Accuracy Estimate 0.047 (lower is better)

ZigZag Offset Segment 5

Duration 5.96 s, Accuracy Estimate 0.076 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.51}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.56}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.8832838896594684}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9171055622576558}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5815761518886456}